IL23 signaling pathway IL23 plays important role in expanding and maintaining the Th17 cell population, a novel Tcell subset involved in antimicrobial immune response and establishment of many autoimmune diseases 1 IL23 receptor is composed of IL12RB1 and IL23R IL23R associates with JAK2 and in a liganddependent manner with STAT3 2The role of the IL23/Th17 pathway in cardiometabolic comorbidity associated with psoriasis Egeberg A(1), Gisondi P(2), Carrascosa JM(3), Warren RB(4), Mrowietz U(5) Author information (1)Gentofte Hospital, Department of Dermatology and Allergy Hellerup, Denmark (2)Section of Dermatology and Venereology, University of Verona, Verona, ItalyTogether, these findings demonstrate an important role for the IL23IL17 immune pathway in host defense against P carinii during infection Infection models using IL12p40−/− and IL12p35−/− mice have shown that there is an IL12p40dependent,
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